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Livres
Articles (141)
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The biochemical basis of hereditary fructose intolerance

Nadia Bouteldja, David J. Timson

Journal:

Journal of Inherited Metabolic Disease

Année:

2010

Langue:

english

Fichier:

PDF, 297 KB

english, 2010

DNA ligases in the repair and replication of DNA

David J Timson, Martin R Singleton, Dale B Wigley

Journal:

Mutation Research/DNA Repair

Année:

2000

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2000

Adolescents who self-harm: Professional staff knowledge, attitudes and training needs

Timson, Debbie, Priest, Helena, Clark-Carter, David

Journal:

Journal of Adolescence

Année:

2012

Langue:

english

Fichier:

PDF, 142 KB

english, 2012

The molecular basis of galactosemia — Past, present and future

Timson, David J.

Journal:

Gene

Année:

2015

Langue:

english

Fichier:

PDF, 762 KB

english, 2015

NAD(P)H quinone oxidoreductase 1 (NQO1): an enzyme which needs just enough mobility, in just the right places

Pey, Angel L., Megarity, Clare F, Timson, David J

Journal:

Bioscience Reports

Année:

2018

Langue:

english

Fichier:

PDF, 757 KB

english, 2018

Catalytic Mechanism of Mevalonate Kinase Revisited, a QM/MM Study

McClory, James, Lin, Jun-Tang, Zhang, Jian, Timson, David J, Huang, M

Journal:

Organic & Biomolecular Chemistry

Année:

2019

Fichier:

PDF, 880 KB

2019

Athletic Training Student Communication: What They Need to Talk About

Carr, W. David, Timson, Ben, Volberding, Jennifer

Journal:

Athletic Training Education Journal

Année:

2018

Langue:

english

Fichier:

PDF, 146 KB

english, 2018

The roles and applications of chaotropes and kosmotropes in industrial fermentation processes

Timson, David J.

Journal:

World Journal of Microbiology and Biotechnology

Année:

2020

Fichier:

PDF, 845 KB

2020

Increased Promiscuity of Human Galactokinase Following Alteration of a Single Amino Acid Residue Distant from the Active Site

Helena Kristiansson, Dr. David J. Timson

Journal:

ChemBioChem

Année:

2011

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2011

The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase

Thomas J. McCorvie, David J. Timson

Journal:

IUBMB Life

Année:

2011

Langue:

english

Fichier:

PDF, 276 KB

english, 2011

Structural and molecular biology of type I galactosemia: Disease-associated mutations

Thomas J. McCorvie, David J. Timson

Journal:

IUBMB Life

Année:

2011

Langue:

english

Fichier:

PDF, 431 KB

english, 2011

The GAL genetic switch: visualisation of the interacting proteins by split-EGFP bimolecular fluorescence complementation

Emma Barnard, David J. Timson

Journal:

Journal of Basic Microbiology

Année:

2011

Langue:

english

Fichier:

PDF, 239 KB

english, 2011

The role of the active site residues in human galactokinase: Implications for the mechanisms of GHMP kinases

Clare F. Megarity, Meilan Huang, Claire Warnock, David J. Timson

Journal:

Bioorganic Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 658 KB

english, 2011

In silico identification and biochemical characterization of novel inhibitors of NQO1

Karen A. Nolan, David J. Timson, Ian J. Stratford, Richard A. Bryce

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 410 KB

english, 2006

Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay

Sevvel Pathmanathan, Emma Barnard, David J. Timson

Journal:

Cell Biology International

Année:

2008

Langue:

english

Fichier:

PDF, 295 KB

english, 2008

Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides

Emma Chambers, Elizabeth M. Hoey, Alan Trudgett, Ian Fairweather, David J. Timson

Journal:

Veterinary Parasitology

Année:

2010

Langue:

english

Fichier:

PDF, 285 KB

english, 2010

Functional analysis of disease-causing mutations in human galactokinase

David J. Timson, Richard J. Reece

Journal:

FEBS Journal

Année:

2003

Langue:

english

Fichier:

PDF, 277 KB

english, 2003

Sugar recognition by human galactokinase

David J Timson, Richard J Reece

Journal:

BMC Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 1.62 MB

english, 2003

Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug

Emma Chambers, Louise A. Ryan, Elizabeth M. Hoey, Alan Trudgett, Neil V. McFerran, Ian Fairweather, David J. Timson

Journal:

Parasitology Research

Année:

2010

Langue:

english

Fichier:

PDF, 316 KB

english, 2010

IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B

Sevvel Pathmanathan, Sarah F. Elliott, Sara McSwiggen, Brett Greer, Pat Harriott, G. Brent Irvine, David J. Timson

Journal:

Molecular and Cellular Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 396 KB

english, 2008

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change

David F. Houston, David J. Timson

Journal:

Molecular and Cellular Biochemistry

Année:

2011

Langue:

english

Fichier:

PDF, 333 KB

english, 2011

N-acetylgalactosamine Kinase: A Naturally Promiscuous Small Molecule Kinase

Helena Kristiansson, David J. Timson

Journal:

Applied Biochemistry and Biotechnology

Année:

2012

Langue:

english

Fichier:

PDF, 276 KB

english, 2012

Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p

Aaron Scott, David J. Timson

Journal:

FEMS Yeast Research

Année:

2007

Langue:

english

Fichier:

PDF, 161 KB

english, 2007

Artemisinins act through at least two targets in a yeast model

Catherine M. Moore, Elizabeth M. Hoey, Alan Trudgett, David J. Timson

Journal:

FEMS Yeast Research

Année:

2011

Langue:

english

Fichier:

PDF, 220 KB

english, 2011

Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase

David J. Timson

Journal:

FEBS Journal

Année:

2005

Langue:

english

Fichier:

PDF, 315 KB

english, 2005

Functional domains of the human epididymal protease inhibitor, eppin

Maelíosa T. C. McCrudden, Tim R. Dafforn, David F. Houston, Philip T. Turkington, David J. Timson

Journal:

FEBS Journal

Année:

2008

Langue:

english

Fichier:

PDF, 314 KB

english, 2008

The structural and molecular biology of type III galactosemia

David J. Timson

Journal:

IUBMB Life

Année:

2006

Langue:

english

Fichier:

PDF, 426 KB

english, 2006

Coumarin-Based Inhibitors of Human NAD(P)H:Quinone Oxidoreductase-1. Identification, Structure–Activity, Off-Target Effects and In Vitro Human Pancreatic Cancer Toxicity

Nolan, Karen A., Zhao, He, Faulder, Paul F., Frenkel, A. David, Timson, David J., Siegel, David, Ross, David, Burke Jr., Terrence R., Stratford, Ian J., Bryce, Richard A.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2007

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

Weiru Liu, Anbu Yue, David J. Timson

Journal:

Computer Methods and Programs in Biomedicine

Année:

2010

Langue:

english

Fichier:

PDF, 822 KB

english, 2010

Fasciola hepatica expresses multiple α- and β-tubulin isotypes

Louise A. Ryan, Elizabeth Hoey, Alan Trudgett, Ian Fairweather, Marc Fuchs, Mark W. Robinson, Emma Chambers, David J. Timson, Eimear Ryan, Theresa Feltwell, Al Ivens, Geoffrey Bentley, David Johnston

Journal:

Molecular and Biochemical Parasitology

Année:

2008

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2008

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

Carla M. Yuede, Scott D. Zimmerman, Hongxin Dong, Matthew J. Kling, Adam W. Bero, David M. Holtzman, Benjamin F. Timson, John G. Csernansky

Journal:

Neurobiology of Disease

Année:

2009

Langue:

english

Fichier:

PDF, 740 KB

english, 2009

Structure of the adenylation domain of an NAD+-dependent DNA ligase

Martin R Singleton, Kjell Håkansson, David J Timson, Dale B Wigley

Journal:

Structure

Année:

1999

Langue:

english

Fichier:

PDF, 776 KB

english, 1999

The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function

David J. Timson, Hylary R. Trayer, Ian P. Trayer

Journal:

FEBS Journal

Année:

1998

Langue:

english

Fichier:

PDF, 487 KB

english, 1998

The Molecular Dynamics of Trypanosoma brucei UDP-Galactose 4′-Epimerase: A Drug Target for African Sleeping Sickness

Aaron J. Friedman, Jacob D. Durrant, Levi C. T. Pierce, Thomas J. McCorvie, David J. Timson, J. Andrew McCammon

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 3.11 MB

english, 2012

Hydrophobic substances induce water stress in microbial cells

Prashanth Bhaganna, Rita J. M. Volkers, Andrew N. W. Bell, Kathrin Kluge, David J. Timson, John W. McGrath, Harald J. Ruijssenaars, John E. Hallsworth

Journal:

Microbial Biotechnology

Année:

2010

Langue:

english

Fichier:

PDF, 982 KB

english, 2010

Functional domains of an NAD+-dependent DNA ligase

David J Timson, Dale B Wigley

Journal:

Journal of Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 264 KB

english, 1999

In vivo and in vitro function of human UDP-galactose 4′-epimerase variants

Thomas J. McCorvie, Jamie Wasilenko, Ying Liu, Judith L. Fridovich-Keil, David J. Timson

Journal:

Biochimie

Année:

2011

Langue:

english

Fichier:

PDF, 686 KB

english, 2011

Detection and localisation of protein–protein interactions in Saccharomyces cerevisiae using a split-GFP method

Emma Barnard, Neil V. McFerran, Alan Trudgett, John Nelson, David J. Timson

Journal:

Fungal Genetics and Biology

Année:

2008

Langue:

english

Fichier:

PDF, 481 KB

english, 2008

Plume characteristics and dynamics of UV and IR laser-desorbed oligonucleotides

Tony L. Merrigan, David J. Timson, C. Adam Hunniford, Martin Catney, Robert W. McCullough

Journal:

International Journal of Biological Macromolecules

Année:

2012

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2012

Substrate Specificity and Mechanism from the Structure of Pyrococcus furiosus Galactokinase

Andrew Hartley, Steven E. Glynn, Vladimir Barynin, Patrick J. Baker, Svetlana E. Sedelnikova, Corné Verhees, Daniel de Geus, John van der Oost, David J. Timson, Richard J. Reece, David W. Rice

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 3.44 MB

english, 2004

Identification and characterisation of human aldose 1-epimerase

David J. Timson, Richard J. Reece

Journal:

FEBS Letters

Année:

2003

Langue:

english

Fichier:

PDF, 521 KB

english, 2003

The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex

David J Timson, Ian P Trayer

Journal:

FEBS Letters

Année:

1997

Langue:

english

Fichier:

PDF, 1.38 MB

english, 1997

Kinetic analysis of yeast galactokinase: implications for transcriptional activation of the GAL genes

David J. Timson, Richard J. Reece

Journal:

Biochimie

Année:

2002

Langue:

english

Fichier:

PDF, 141 KB

english, 2002

Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin

David J. Timson

Journal:

Biochimie

Année:

2003

Langue:

english

Fichier:

PDF, 315 KB

english, 2003

IQ-motif peptides as novel anti-microbial agents

McLean, Denise T.F., Lundy, Fionnuala T., Timson, David J.

Journal:

Biochimie

Année:

2013

Langue:

english

Fichier:

PDF, 709 KB

english, 2013

A plasma membrane Ca2+-ATPase (PMCA) from the liver fluke, Fasciola hepatica

Catherine M. Moore, Elizabeth M. Hoey, Alan Trudgett, David J. Timson

Journal:

International Journal for Parasitology

Année:

2012

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2012

Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus

James A Brannigan, Stephen R Ashford, Aidan J Doherty, David J Timson, Dale B Wigley

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1999

Langue:

english

Fichier:

PDF, 506 KB

english, 1999

FhCaBP4: aFasciola hepaticacalcium-binding protein with EF-hand and dynein light chain domains

Rebecca Orr, Ruth Kinkead, Richard Newman, Lindsay Anderson, Elizabeth M. Hoey, Alan Trudgett, David J. Timson

Journal:

Parasitology Research

Année:

2012

Langue:

english

Fichier:

PDF, 376 KB

english, 2012

A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1

Andrews, William J., Bradley, Conor A., Hamilton, Elaine, Daly, Clare, Mallon, Thérèse, Timson, David J.

Journal:

Molecular and Cellular Biochemistry

Année:

2012

Langue:

english

Fichier:

PDF, 375 KB

english, 2012

Altered cofactor binding affects stability and activity of human UDP-galactose 4′-epimerase: Implications for type III galactosemia

Thomas J. McCorvie, Ying Liu, Andrew Frazer, Tyler J. Gleason, Judith L. Fridovich-Keil, David J. Timson

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2012

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2012